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1

Site-directed conjugation of nonpeptide groups to peptides and proteins via periodate oxidation of a 2-amino alcohol. Application to modification at N-terminal serine

Geoghegan, Kieran F., Stroh, Justin G.

Journal:

Bioconjugate Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 1.40 MB

english, 1992

2

Risk factors associated with increased mortality of farmed Pacific oysters in Ireland during 2011

Clegg, Tracy A., Morrissey, Teresa, Geoghegan, Fiona, Martin, S. Wayne, Lyons, Kieran, Ashe, Seán, More, Simon J.

Journal:

Preventive Veterinary Medicine

Année:

2014

Langue:

english

Fichier:

PDF, 1.82 MB

english, 2014

3

Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins

Wu, Jiang, Shin, Julia, Williams, Cara M. M., Geoghegan, Kieran F., Wright, Stephen W., Limburg, David C., Sahasrabudhe, Parag, Bonin, Paul D., Lefker, Bruce A., Ramsey, Simeon J.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 499 KB

english, 2014

4

Chemoproteomics Demonstrates Target Engagement and Exquisite Selectivity of the Clinical Phosphodiesterase 10A Inhibitor MP-10 in Its Native Environment

Schülke, Jan-Philip, McAllister, Laura A., Geoghegan, Kieran F., Parikh, Vinod, Chappie, Thomas A., Verhoest, Patrick R., Schmidt, Christopher J., Johnson, Douglas S., Brandon, Nicholas J.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 18.67 MB

english, 2014

5

Correction: Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins

Wu, Jiang, Shin, Julia, Williams, Cara M. M., Geoghegan, Kieran F., Wright, Stephen W., Limburg, David C., Sahasrabudhe, Parag, Bonin, Paul D., Lefker, Bruce A., Ramsey, Simeon J.

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 146 KB

english, 2015

6

Biochemical applications of mass spectrometry in pharmaceutical drug discovery

Kieran F. Geoghegan, Michele A. Kelly

Journal:

Mass Spectrometry Reviews

Année:

2005

Langue:

english

Fichier:

PDF, 583 KB

english, 2005

7

Spontaneous α-N-6-Phosphogluconoylation of a “His Tag” inEscherichia coli:The Cause of Extra Mass of 258 or 178 Da in Fusion Proteins

Kieran F. Geoghegan, Henry B.F. Dixon, Philip J. Rosner, Lise R. Hoth, Anthony J. Lanzetti, Kris A. Borzilleri, Eric S. Marr, Linda H. Pezzullo, LeRoy B. Martin, Peter K. LeMotte, Alexander S. McColl,

Journal:

Analytical Biochemistry

Année:

1999

Langue:

english

Fichier:

PDF, 299 KB

english, 1999

8

Modification of amyloid-β(1–40) by a protease inhibitor creates risk of error in mass spectrometric quantitation of amyloid-β(1–42)

James J. Conboy, Kathleen G. Wood, Mary E. Lame, Robert A. Durham, Kieran F. Geoghegan

Journal:

Analytical Biochemistry

Année:

2008

Langue:

english

Fichier:

PDF, 188 KB

english, 2008

9

Synthesis and biological activity of selective pipecolic acid-based TNF-α converting enzyme (TACE) inhibitors

Michael A. Letavic, Matt Z. Axt, John T. Barberia, Thomas J. Carty, Dennis E. Danley, Kieran F. Geoghegan, Nadia S. Halim, Lise R. Hoth, Ajith V. Kamath, Ellen R. Laird, Lori L. Lopresti-Morrow, Kim F

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 134 KB

english, 2002

10

Preliminary x-ray analysis of crystals of plasminogen activator inhibitor-1

Dr. Elizabeth J. Goldsmith, Chen Sheng-Cheng, Dennis E. Danley, Robert D. Gerard, Kieran F. Geoghegan, James Mottonen, Arne Strand

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

1991

Langue:

english

Fichier:

PDF, 341 KB

english, 1991

11

Tandem mass spectrometry of multiply phosphorylated forms of a ‘histidine-tag’ derived from a recombinant protein kinase expressed in bacteria

Ping Du, Pat Loulakis, Zhi Xie, Samuel P. Simons, Kieran F. Geoghegan

Journal:

Rapid Communications in Mass Spectrometry

Année:

2005

Langue:

english

Fichier:

PDF, 123 KB

english, 2005

12

X-ray analysis of HIV-1 proteinase at 2.7 Å resolution confirms structural homology among retroviral enzymes

Lapatto, Risto, Blundell, Tom, Hemmings, Andrew, Overington, John, Wilderspin, Andrew, Wood, Stephen, Merson, James R., Whittle, Peter J., Danley, Dennis E., Geoghegan, Kieran F.

Journal:

Année:

1989

Fichier:

PDF, 440 KB

1989

13

Structural basis of latency in plasminogen activator inhibitor-1

Mottonen, James, Strand, Arne, Symersky, Jindrich, Sweet, Robert M., Danley, Dennis E., Geoghegan, Kieran F., Gerard, Robert D., Goldsmith, Elizabeth J.

Journal:

Année:

1992

Fichier:

PDF, 930 KB

1992

14

Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules

Qiu, Xiayang, Mistry, Anil, Ammirati, Mark J, Chrunyk, Boris A, Clark, Ronald W, Cong, Yang, Culp, Jeffrey S, Danley, Dennis E, Freeman, Thomas B, Geoghegan, Kieran F

Journal:

Nature Structural and Molecular Biology

Année:

2007

Langue:

english

Fichier:

PDF, 832 KB

english, 2007

15

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

Cunningham, David, Danley, Dennis E, Geoghegan, Kieran F, Griffor, Matthew C, Hawkins, Julie L, Subashi, Timothy A, Varghese, Alison H, Ammirati, Mark J, Culp, Jeffrey S, Hoth, Lise R

Journal:

Nature Structural and Molecular Biology

Année:

2007

Langue:

english

Fichier:

PDF, 667 KB

english, 2007

16

The 2.0 Å crystal structure of the ERα ligand-binding domain complexed with lasofoxifene

Felix F. Vajdos, Lise R. Hoth, Kieran F. Geoghegan, Samuel P. Simons, Peter K. LeMotte, Dennis E. Danley, Mark J. Ammirati, Jayvardhan Pandit

Journal:

Protein Science

Année:

2007

Langue:

english

Fichier:

PDF, 627 KB

english, 2007

17

Isolation and characterization of biologically active murine interleukin-1α derived from expression of a synthetic gene in Escherichia coli

Gaston O. Daumy, Joseph M. Merenda, Alexander S. McColl, Glenn C. Andrews, Arthur E. Franke, Kieran F. Geoghegan, Ivan G. Otterness

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1989

Langue:

english

Fichier:

PDF, 4.14 MB

english, 1989

18

Expression of human plasminogen activator inhibitor type-1 (PAI-1) in Escherichia coli as a soluble protein comprised of active and latent forms. Isolation and crystallization of latent PAI-1

Arthur E. Franke, Dennis E. Danley, Frank S. Kaczmarek, Steven J. Hawrylik, Robert D. Gerard, S.Edward Lee, Kieran F. Geoghegan

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1990

Langue:

english

Fichier:

PDF, 835 KB

english, 1990

19

Characterization of a novel 14 kDa bile acid-binding protein from rat ileal cytosol

Marie C. Lin, Yongzhong Gong, Kieran F. Geoghegan, Frederick A. Wilson

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1991

Langue:

english

Fichier:

PDF, 1.19 MB

english, 1991

20

ALTERNATIVE REDUCING AGENTS FOR REDUCTIVE METHYLATION OF AMINO GROUPS IN PROTEINS

KIERAN F. GEOGHEGAN, JUDY C. CABACUNGAN, HENRY B.F. DIXON, ROBERT E. FEENEY

Journal:

Chemical Biology & Drug Design

Année:

1981

Langue:

english

Fichier:

PDF, 572 KB

english, 1981

21

Crystallizable HIV-1 protease derived from expression of the viral pol gene in Escherichia coli

Dennis E. Danley, Kieran F. Geoghegan, Kathryn G. Scheld, S.Edward Lee, James R. Merson, Steven J. Hawrylik, Graham A. Rickett, Mark J. Ammirati, Peter M. Hobart

Journal:

Biochemical and Biophysical Research Communications

Année:

1989

Langue:

english

Fichier:

PDF, 1.63 MB

english, 1989

22

Identification of the 14 kDa bile acid transport protein of rat ileal cytosol as gastrotropin

Alex D. Vodenlich Jr., Yong-Zhong Gong, Kieran F. Geoghegan, Marie C. Lin, Anthony J. Lanzetti, Frederick A. Wilson

Journal:

Biochemical and Biophysical Research Communications

Année:

1991

Langue:

english

Fichier:

PDF, 704 KB

english, 1991

23

Fluorescence-based continuous assay for the aspartyl protease of human immunodeficiency virus-1

Kieran F. Geoghegan, Robin W. Spencer, Dennis E. Danley, Leonard G. Contillo Jr., Glenn C. Andrews

Journal:

Année:

1990

Langue:

english

Fichier:

PDF, 418 KB

english, 1990

24

Reduction of biological activity of murine recombinant interleukin-1β by selective deamidation at asparagine-149

Gaston O. Daumy, Cheryl L. Wilder, Joseph M. Merenda, Alexander S. McColl, Kieran F. Geoghegan, Ivan G. Otterness

Journal:

Année:

1991

Langue:

english

Fichier:

PDF, 1.21 MB

english, 1991

25

Identification of the residue responsible for catalysing regeneration of activity in the inactive glutamate dehydrogenase mutant D165N

Francesca Paradisi, Ruth Woolfson, Kieran F. Geoghegan, Paul C. Engel

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 77 KB

english, 2005

26

The discovery of four distinct glutamate dehydrogenase genes in a strain of Halobacterium salinarum

Lorna M. Ingoldsby, Kieran F. Geoghegan, Bronagh M. Hayden, Paul C. Engel

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 175 KB

english, 2005

27

Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene

Niamh Banville, Robert Geraghty, Edward Fox, Dermot T. Leahy, Andrew Green, Denise Keegan, Justin Geoghegan, Diarmuid O'Donoghue, John Hyland, Kieran Sheahan

Journal:

Human Pathology

Année:

2006

Langue:

english

Fichier:

PDF, 849 KB

english, 2006

28

Phosphorylation of serine residues in histidine-tag sequences attached to recombinant protein kinases: A cause of heterogeneity in mass and complications in function

Ping Du, Pat Loulakis, Chun Luo, Anil Mistry, Samuel P. Simons, Peter K. LeMotte, Francis Rajamohan, Kristina Rafidi, Kevin G. Coleman, Kieran F. Geoghegan, Zhi Xie

Journal:

Protein Expression and Purification

Année:

2005

Langue:

english

Fichier:

PDF, 393 KB

english, 2005

29

Expression and protein chemistry yielding crystallization of the catalytic domain of ADAM17 complexed with a hydroxamate inhibitor

Lise R. Hoth, Douglas H. Tan, Ing-Kae Wang, Paul A. Wengender, Michelle A. Thompson, Ajith V. Kamath, Kieran F. Geoghegan

Journal:

Protein Expression and Purification

Année:

2007

Langue:

english

Fichier:

PDF, 404 KB

english, 2007

30

Initiation of translation at an upstream non-AUG codon accounting for N-terminally extended minor forms of recombinant proteins expressed in insect cells

Kieran F. Geoghegan, Xidong Feng, Jeanne S. Chang, Kerry Kelleher, Paul W. Wu, Laura Lin, Francis Rajamohan

Journal:

Protein Expression and Purification

Année:

2011

Langue:

english

Fichier:

PDF, 840 KB

english, 2011

31

Escherichia coli expression, purification and characterization of functional full-length recombinant α2β2γ3 heterotrimeric complex of human AMP-activated protein kinase

Francis Rajamohan, Melissa S. Harris, Richard K. Frisbie, Lise R. Hoth, Kieran F. Geoghegan, James J. Valentine, Allan R. Reyes, James A. Landro, Xiayang Qiu, Ravi G. Kurumbail

Journal:

Protein Expression and Purification

Année:

2010

Langue:

english

Fichier:

PDF, 911 KB

english, 2010

32

IP/MS analysis of human CSF Aβ following a single dose of the C-terminal anti-Aβ antibody ponezumab (PF-04360365) to Alzheimer patients

Kathleen M. Wood, Frederick McCush, James J. Conboy, Robert Durham, Barbara Tate, Martin M. Bednar, Jaren W. Landen, Kieran F. Geoghegan, Kelly R. Bales

Journal:

Alzheimer's & Dementia

Année:

2010

Langue:

english

Fichier:

PDF, 43 KB

english, 2010

33

Distinctive Attributes of β-Lactam Target Proteins in Acinetobacter baumannii Relevant to Development of New Antibiotics

Han, Seungil, Caspers, Nicole, Zaniewski, Richard P., Lacey, Brian M., Tomaras, Andrew P., Feng, Xidong, Geoghegan, Kieran F., Shanmugasundaram, Veerabahu

Journal:

Journal of the American Chemical Society

Année:

2011

Langue:

english

Fichier:

PDF, 3.97 MB

english, 2011

34

Initial impact of a systematic multidisciplinary approach on the management of patients with gastroenteropancreatic neuroendocrine tumor

Gianluca Tamagno, Kieran Sheahan, Stephen J. Skehan, Justin G. Geoghegan…

Journal:

Endocrine (Springer)

Année:

2013

Langue:

english

Fichier:

PDF, 199 KB

english, 2013

35

[Annual Reports in Medicinal Chemistry] Volume 45 || Chemical Proteomic Technologies for Drug Target Identification

Geoghegan, Kieran F.

Année:

2010

Langue:

english

Fichier:

PDF, 384 KB

english, 2010

36

Improved Method for Converting an Unmodified Peptide to an Energy-Transfer Substrate for a Proteinase

Geoghegan, Kieran F.

Journal:

Bioconjugate Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 244 KB

english, 1996

37

A continuous and direct assay to monitor leucine-rich repeat kinase 2 activity

Silva, Rafael G., Geoghegan, Kieran F., Qiu, Xiayang, Aulabaugh, Ann

Journal:

Analytical Biochemistry

Année:

2014

Langue:

english

Fichier:

PDF, 1.81 MB

english, 2014

38

Unexpected mucin-type O-glycosylation and host-specific N-glycosylation of human recombinant interleukin-17A expressed in a human kidney cell line

Geoghegan, Kieran F., Song, Xi, Hoth, Lise R., Feng, Xidong, Shanker, Suman, Quazi, Amira, Luxenberg, Deborah P., Wright, Jill F., Griffor, Matthew C.

Journal:

Protein Expression and Purification

Année:

2013

Langue:

english

Fichier:

PDF, 986 KB

english, 2013

39

ACUTE RENAL FAILURE IN OBSTETRICS

O'Driscoll, Kieran, Geoghegan, Francis

Journal:

Année:

1965

Langue:

english

Fichier:

PDF, 358 KB

english, 1965

40

[Part 1: Biological Sciences] || Cryospectrokinetic Characterization of Intermediates in Biochemical Reactions: Carboxypeptidase A

David S. Auld, Alphonse Galdes, Kieran F. Geoghegan, Barton Holmquist, Richard A. Martinelli and Bert L. Vallee

Journal:

Proceedings of the National Academy of Sciences

Année:

1984

Langue:

english

Fichier:

PDF, 1.20 MB

english, 1984

41

Cyclization of N-Terminal S- Carbamoylmethylcysteine Causing Loss of 17 Da from Peptides and Extra Peaks in Peptide Maps

Geoghegan, Kieran F., Hoth, Lise R., Tan, Douglas H., Borzilleri, Kris A., Withka, Jane M., Boyd, James G.

Journal:

Journal of Proteome Research

Année:

2002

Langue:

english

Fichier:

PDF, 110 KB

english, 2002

42

Protein Science

Review by: Kieran F. Geoghegan

Journal:

Année:

1980

Langue:

english

Fichier:

PDF, 116 KB

english, 1980

43

Spectral properties of cobalt carboxypeptidase A. Interaction of the metal atom with anions

Geoghegan, Kieran F., Holmquist, Barton, Spilburg, Curtis A., Vallee, Bert L.

Journal:

Année:

1983

Langue:

english

Fichier:

PDF, 745 KB

english, 1983

44

Binding to the Low-Density Lipoprotein Receptor Accelerates Futile Catalytic Cycling in PCSK9 and Raises the Equilibrium Level of Intramolecular Acylenzyme

Geoghegan, Kieran F., Hoth, Lise R., Varghese, Alison H., Lin, Wen, Boyd, James G., Griffor, Matthew C.

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 1.73 MB

english, 2009

45

Hydrolysis of peptides by carboxypeptidase A: equilibrium trapping of the ES2 intermediate

Geoghegan, Kieran F., Galdes, Alphonse, Hanson, Graeme, Holmquist, Barton, Auld, David S., Vallee, Bert L.

Journal:

Année:

1986

Langue:

english

Fichier:

PDF, 751 KB

english, 1986

46

Site-directed double fluorescent tagging of human renin and collagenase (MMP-1) substrate peptides using the periodate oxidation of N-terminal serine. An apparently general strategy for provision of energy-transfer substrates for proteases

Geoghegan, Kieran F., Emery, Michael J., Martin, William H., McColl, Alexander S., Daumy, Gaston O.

Journal:

Bioconjugate Chemistry

Année:

1993

Langue:

english

Fichier:

PDF, 1.01 MB

english, 1993

47

Chemical and Biochemical Issues Related to X-ray Crystallography of the Ligand-Binding Domain of Estrogen Receptor α

Goldstein, Steven W., Bordner, Jon, Hoth, Lise R., Geoghegan, Kieran F.

Journal:

Bioconjugate Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 128 KB

english, 2001

48

Cryospectroscopy of intermediates in the mechanism of carboxypeptidase A

Geoghegan, Kieran F., Galdes, Alphonse, Martinelli, Richard A., Holmquist, Barton, Auld, David S., Vallee, Bert L.

Journal:

Année:

1983

Langue:

english

Fichier:

PDF, 1.02 MB

english, 1983

49

Dye-Pair Reporter Systems for Protein−Peptide Molecular Interactions

Geoghegan, Kieran F., Rosner, Philip J., Hoth, Lise R.

Journal:

Bioconjugate Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 355 KB

english, 2000

50

Reversible reductive alkylation of amino groups in proteins

Geoghegan, Kieran F., Ybarra, Donna M., Feeney, Robert E.

Journal:

Année:

1979

Langue:

english

Fichier:

PDF, 995 KB

english, 1979